Diazepam

Pharmacogenomic Information in the Context of the FDA-Approved Drug Label*

Diazepam is used mainly for treatment of anxiety and anxiety disorders and also for treatment of other issues including seizures, muscle spasms and irritable bowel syndrome. CYP2C19 is involved in its metabolism.

Excerpts from the Diazepam drug label:

"Diazepam is N-demethylated by CYP3A4 and 2C19 to the active metabolite N-desmethyldiazepam, and is hydroxylated by CYP3A4 to the active metabolite temazepam."

"There is a potentially relevant interaction between diazepam and compounds which inhibit certain hepatic enzymes (particularly
cytochrome P450 3A and 2C19."

(For the complete drug label text with sections containing pharmacogenetic information highlighted, see the Diazepam drug label PDF.)