Propanolol

Pharmacogenomic Information in the Context of the FDA-Approved Drug Label*

Propanolol is a beta-blocker which is used for treatment of various conditions including hypertension, angina pectoris and migraine.

Excerpt from the propanolol drug label:

"In healthy subjects, no difference was observed between CYP2D6 extensive metabolizers (EMs) and poor metabolizers (PMs) with respect to oral clearance or elimination half-life. Partial clearance of 4-hydroxy propranolol was significantly higher and naphthyloxyactic acid was significantly lower in EMs than PMs."

(For the complete drug label text with sections containing pharmacogenetic information highlighted, see the Propanolol drug label PDF.)