PharmGKB contains no dosing guidelines for this gene. To report known dosing guidelines, or if you are interested in developing guidelines, click here.
PharmGKB contains no drug labels with pharmacogenomic information for this gene. To report a drug label with PGx, click here.
PharmGKB contains no clinical annotations for this gene. To report clinical variants, click here.
PharmGKB contains no genetic tests for this gene. To report genetic tests, click here.
Overview
| Alternate Names: | A4 amyloid protein; Amyloid beta (A4) precursor protein; OTTHUMP00000096096; PN-II; alzheimer disease amyloid protein; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease); amyloid beta A4 protein; amyloid beta-peptide; amyloid-beta protein; beta-amyloid peptide; cerebral vascular amyloid peptide; human mRNA for amyloid A4 precursor of Alzheimer's disease; peptidase nexin-II; preA4; protease nexin-II |
|---|---|
| Alternate Symbols: | AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN2 |
| PharmGKB Accession Id: | PA24910 |
Details
| Cytogenetic Location: | chr21 : q21.3 - q21.3 |
|---|---|
| GP mRNA Boundary†: | chr21 : 27252861 - 27543446 |
| GP Gene Boundary†: | chr21 : 27249861 - 27553446 |
| Strand: | minus |
| Product Name: | No data available |
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.
External Pathways
Links to non-PharmGKB pathways.
- Caspase cascade in apoptosis - (Pathway Interaction Database NCI-Nature Curated)
- Exocytosis of Alpha granule - (Reactome via Pathway Interaction Database)
- generation of amyloid b-peptide by ps1 - (BioCarta via Pathway Interaction Database)
- Glypican 1 network - (Pathway Interaction Database NCI-Nature Curated)
- p75(NTR)-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
- platelet amyloid precursor protein pathway - (BioCarta via Pathway Interaction Database)
Publications related to APP: 14
LinkOuts
- Entrez Gene:
- 351
- OMIM:
- 104300
- 104760
- 605714
- UCSC Genome Browser:
- NM_000484
- RefSeq RNA:
- NM_000484
- NM_001136016
- NM_001136129
- NM_001136130
- NM_001136131
- NM_201413
- NM_201414
- RefSeq Protein:
- NP_000475
- NP_001129488
- NP_001129601
- NP_001129602
- NP_001129603
- NP_958816
- NP_958817
- RefSeq DNA:
- AC_000064
- AC_000153
- NC_000021
- NG_007376
- NT_011512
- NW_001838706
- NW_927384
- UniProtKB:
- B4DGD0_HUMAN (B4DGD0)
- A4_HUMAN (P05067)
- Ensembl:
- ENSG00000142192
- GenAtlas:
- APP
- GeneCard:
- GC21M027252 (351)