PharmGKB contains no dosing guidelines for this gene. To report known dosing guidelines, or if you are interested in developing guidelines, click here.
PharmGKB contains no drug labels with pharmacogenomic information for this gene. To report a drug label with PGx, click here.
PharmGKB contains no clinical annotations for this gene. To report clinical variants, click here.
PharmGKB contains no genetic tests for this gene. To report genetic tests, click here.
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.
Links in the "Drugs" column lead to PharmGKB Drug Pages.
|
Variant?
(build 132) |
Alternate Names ? | Drugs ? |
Alleles
?
(+ chr strand) |
Function ? |
Amino Acid?
Translation |
|
|---|---|---|---|---|---|---|
| rs1800566 | NQO1*2, NQO1:C609T, NQO1:P187S, NQO1:c.558C>T, c.445C>T, c.457C>T, c.559C>T, g.20389C>T, g.23359344G>A, p.Pro149Ser, p.Pro153Ser, p.Pro187Ser, rs1800566 C>T |
G > A
|
Missense |
Pro149Ser
|
Overview
| Alternate Names: | DT-diaphorase; NAD(P)H dehydrogenase [quinone] 1; NAD(P)H menadione oxidoreductase 1, dioxin-inducible; NAD(P)H:Quinone acceptor oxidoreductase type 1; NAD(P)H:menadione oxidoreductase 1; NAD(P)H:menadione oxidoreductase 1, dioxin-inducible 1; NAD(P)H:quinone oxidoreductase 1; NAD(P)H:quinone oxireductase; azoreductase; diaphorase (NADH/NADPH); diaphorase (NADH/NADPH) (cytochrome b-5 reductase); diaphorase-4; dioxin-inducible 1; menadione reductase; phylloquinone reductase; quinone reductase 1 |
|---|---|
| Alternate Symbols: | DHQU; DIA4; DTD; NMOR1; NMORI; QR1 |
| PharmGKB Accession Id: | PA31744 |
Details
| Cytogenetic Location: | chr16 : q22.1 - q22.1 |
|---|---|
| GP mRNA Boundary†: | chr16 : 69743304 - 69760533 |
| GP Gene Boundary†: | chr16 : 69740304 - 69770533 |
| Strand: | minus |
| Product Name: | No data available |
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
-
Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
Representation of the candidate genes involved in the action of doxorubicin in a stylized cancer cell.
-
Doxorubicin Pathway, Pharmacokinetics
Diagrammatic representation of the transport and metabolism of doxorubicin.
-
Phenytoin Pathway, Pharmacokinetics
Genes involved in the metabolism of phenytoin in the human liver cell.
-
Platinum Pathway, Pharmacokinetics/Pharmacodynamics
Representation of the candidate genes involved in the metabolism of platinum containing drugs.
External Pathways
Links to non-PharmGKB pathways.
Curated Information ?
| Evidence | Drug |
|---|---|
| 1-methyloxy-4-sulfone-benzene | |
| cisplatin | |
| cyclophosphamide | |
| dicumarol | |
| doxorubicin | |
| etoposide |
| Evidence | Drug Class |
|---|---|
| anthracyclines and related substances |
Curated Information ?
| Evidence | Disease |
|---|---|
| Breast Neoplasms | |
| Carcinoma, Non-Small-Cell Lung | |
| Heart Failure | |
| Leukemia | |
| Lung Neoplasms |
Publications related to NQO1: 28
Datasets
- Maximal CBR1 and NQO1 activities in liver cytosols
- Risk of therapy-related acute myeloid leukemia
- Genetic Variants in ADHD Stimulant associated Adverse Events
- Pharmacogenetics of Minimal Residual Disease Response in Children with B-Precursor Acute Lymphoblastic Leukemia (ALL): A Report from the Children's Oncology Group
LinkOuts
- Entrez Gene:
- 1728
- OMIM:
- 125860
- UCSC Genome Browser:
- NM_000903
- RefSeq RNA:
- NM_000903
- NM_001025433
- NM_001025434
- RefSeq Protein:
- NP_000894
- NP_001020604
- NP_001020605
- RefSeq DNA:
- AC_000059
- AC_000148
- NC_000016
- NG_011504
- NT_010498
- NW_001838290
- NW_926462
- UniProtKB:
- B7ZAD1_HUMAN (B7ZAD1)
- NQO1_HUMAN (P15559)
- Ensembl:
- ENSG00000181019
- GenAtlas:
- NQO1
- GeneCard:
- GC16M069744 (1728)
- MutDB:
- NQO1
- ALFRED:
- LO036511Q