PharmGKB contains no dosing guidelines for this gene. To report known dosing guidelines, or if you are interested in developing guidelines, click here.
PharmGKB contains no drug labels with pharmacogenomic information for this gene. To report a drug label with PGx, click here.
PharmGKB contains no Clinical Variants that meet the highest level of criteria.
To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.
| Position ? | Drug ? | Relevance ? |
Strength of Evidence ? |
||
|---|---|---|---|---|---|
Download a summary of all Clinical Annotations available.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
PharmGKB contains no genetic tests for this gene. To report genetic tests, click here.
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.
Links in the "Drugs" column lead to PharmGKB Drug Pages.
|
Variant?
(build 132) |
Alternate Names ? | Drugs ? |
Alleles
?
(+ chr strand) |
Function ? |
Amino Acid?
Translation |
|
|---|---|---|---|---|---|---|
| rs1042713 | 46G>A, ADRB2:16Arg>Gly, ADRB2:Arg16Gly, ADRB2:Gly16Arg, Arg16, c.46A>G, g.5285A>G, g.9369367G>A, p.Arg16Gly | A > G | Missense | Arg16Gly | ||
| rs1042714 | 318C>G, ADRB2:27Glu>Gln, ADRB2:79C>G, ADRB2:Gln27Glu, Gln27, c.79C>G, g.5318C>G, g.9369400G>C, p.Gln27Glu | C > G | Missense | Gln27Glu | ||
| rs1800888 | 491T>C, ADRB2: 164Thr>Ile, Ile164, Thr164Ile, c.491C>T, g.148187078C>T, g.5730C>T, g.9369812C>T, p.Thr164Ile | C > T | Missense | Thr164Ile |
Overview
| Alternate Names: | beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor |
|---|---|
| Alternate Symbols: | ADRB2R; ADRBR; B2AR; BAR; BETA2AR |
| PharmGKB Accession Id: | PA39 |
Details
| Cytogenetic Location: | chr5 : q32 - q32 |
|---|---|
| GP mRNA Boundary†: | chr5 : 148206156 - 148208188 |
| GP Gene Boundary†: | chr5 : 148196156 - 148211188 |
| Strand: | plus |
| Product Name: | No data available |
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
-
Antiarrhythmic Pathway, Pharmacodynamics
Pharmacodynamic pathway of antiarrhythmic drugs in a stylized cardiac myocyte.
-
Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
Simplified pharmacodynamic pathway of drug action on beta 2 adrenergic receptor in a stylized airway cell.
-
Sympathetic Nerve Pathway (Neuroeffector Junction)
Simplified diagram of a sympathetic neuroeffector junction displaying genes which may be involved.
External Pathways
Links to non-PharmGKB pathways.
- Arf6 signaling events - (Pathway Interaction Database NCI-Nature Curated)
- Arf6 trafficking events - (Pathway Interaction Database NCI-Nature Curated)
- corticosteroids and cardioprotection - (BioCarta via Pathway Interaction Database)
- cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway - (BioCarta via Pathway Interaction Database)
- phospholipase c-epsilon pathway - (BioCarta via Pathway Interaction Database)
Datasets
- ADRB2 association with cardiovascular disease
- Blood pressure measurements
- Blood pressure measurements, group 2
- Bronchodilator response to beta agonist in asthmatics
- Cold Pressor Test (CPT) measurements of twins
- Drug-Induced Long QT Intervals
- Genetic Epidemiology of Responses to Antihypertensives (GERA)
- Survival of patients on beta-blockers after ACS, and ADRB1, ADRB2
- A chemogenomic approach to drug discovery: focus on cardiovascular diseases
- Genetic Associations in Drug-induced QT Prolongation and Torsades
- International Multi-Center ADHD Genetics Project (IMAGE)
- Pharmacogenetics of Minimal Residual Disease Response in Children with B-Precursor Acute Lymphoblastic Leukemia (ALL): A Report from the Children's Oncology Group
LinkOuts
- Ensembl:
- ENSG00000169252
- GenAtlas:
- ADRB2
- GeneCard:
- GC05P148186 (154)
- SOURCE:
- ADRB2
- MutDB:
- ADRB2
- PromoLign:
- ortho_2259
- ALFRED:
- LO000206I
Common Searches
Non-Curated Publications
A list of non-curated publications that mention this gene is available.