The Clinical Pharmacogenetics Implementation Consortium (CPIC) has published genotype-based dosing guidelines for CYP2D6 and codeine in Clinical Pharmacology and Therapeutics (CPT). Download the article and supplement.
Clinical Interpretations
Drugs & Small Molecules
CPIC Guidelines
The Clinical Pharmacogenetics Implementation Consortium (CPIC) has published the following PGx-drug dosing guidelines:
- TPMT/thiopurines: article and supplement
- CYP2C19/clopidogrel: article and supplement
- CYP2C9/VKORC1/warfarin: article and supplement
PGx Toolbox
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See the archives for more.
Useful Links
- CPIC Gene-Drug Pairs
- Well Known Pairs of Gene-Drug PGx Relationships
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Subscribe to Example Searches for Clinical Interpretations
1. Search by gene symbol:
This will take you to the FDA label and dosing guideline associated with CYP2C9 and warfarin.
2. Search by drug:
This will return clinical annotations, dosing guidelines and other annotations associated with warfarin.
3. Search by dbSNP reference ID:
This will return the clinical annotation and dosing guideline associated with rs4244285.
Example Searches for Genes
1. Search by gene symbol:
This will take you to the CYP2C9 gene page because there's one exact match.
2. Search by drug:
This will return a list of genes associated with warfarin.
3. Search by disease:
This will return a list of genes associated with myocardial infarction.
4. Search by drug/disease combination:
This will return list of genes associated with both simvastatin AND myopathy.
5. Search by Entrez Gene ID:
This will return a gene with Entrez Gene ID 3949.
6. Search by PubMed ID:
This will return a list of genes linked to PubMed ID 19106083.
7. Search by protein name:
This will return a list of genes containing "glucocorticoid receptor" in their names".
Example Searches for Variants
1. Search by gene symbol:
This will return a list of variants associated with CYP2C9.
2. Search by drug:
This will return a list of variants associated with warfarin.
3. Search by disease:
This will return a list of variants associated with myocardial infarction.
4. Search by gene/drug/disease combination:
This will return list of variants associated with both clopidogrel AND CYP2C19.
5. Search by dbSNP reference ID:
This will take you to the variant page for rs1045642.
6. Search by nucleotide or amino acid change in variant common name:
This will return variants with "G3673A".
7. Search by named alleles (please use "\" in front of "*"):
This will return a list of variants for CYP2C9*3.
8. Search by PubMed ID:
This will return a list of variants linked to PubMed ID 19106083.
Example Searches for Pathways
1. Search by gene symbol:
This will return a list of pathways associated with CYP2C9.
2. Search by drug:
This will return a list of pathways associated with warfarin.
3. Search by disease:
This will return a list of pathways associated with asthma.
4. Search by therapeutic category:
This will return list of pathways associated with Nervous System.
Example Searches for Drugs
1. Search by drug's generic or trade name:
This will take you to the imatinib drug page because there's one exact match (Gleevec is a trade name for imatinib).
2. Search by gene symbol:
This will return a list of drugs associated with CYP2C9.
3. Search by disease:
This will return a list of drugs associated with asthma.
4. Search by gene/disease combination:
This will return list of drugs associated with both UGT1A1 AND colonic neoplasm.
5. Search by DrugBank ID: DB00619:
This will return drug with DrugBank ID: DB00619.
6. Search by PubMed ID:
This will return a list of drugs linked to PubMed ID 19106083.
Example Searches for Diseases
1. Search by disease name:
This will take you to the hypertension disease page because there's one exact match.
2. Search by gene symbol:
This will return a list of diseases associated with TPMT gene.
3. Search by variant name:
This will return a list of diseases associated with variant rs1801133 or 677T>C.
4. Search by drug name:
This will return a list of diseases associated with drug pravastatin.
5. Search by gene/drug combination:
This will return list of diseases associated with both SLCO1B1 AND pravastatin.
6. Search by PubMed ID:
This will return a list of diseases linked to PubMed ID 19106083.
7. Search by SnoMed Clinical Terminology ID:
This will return disease "Breast Neoplasms" with SnoMed Clinical Terminology ID: 126926005.
8. Search by Unified Medical Language System ID:
This will return disease "Hypertension" with Unified Medical Language System ID: C0020538.
9. Search by MeSH ID:
This will return disease "Hypertension" with MeSH ID: D006973.
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©2001-2012 PharmGKB.