Variant:

rs1065776 at chr3:152553628 in P2RY1 (VIP)

Variant Annotations

PharmGKB variant annotations provide information about variant-drug pairs based on individual PubMed publications. Each annotation represents information from a single paper and the goal is to report the information that the author states, not an interpretation of the paper. The PMID for supporting PubMed publications is found in the "Evidence" field.

Information presented, including study size, allele frequencies and statistics is taken directly from the publication. However, if the author does not correct p-values in cases of multiple hypotheses, curators may apply a Bonferroni correction. Curators attempt to report study size based on the actual number of participants used for the calculation of the association statistics, so the number may vary slightly from what is reported in the abstract of the paper. OMB Race Category information is derived from the paper and mapped to standardized categories. Category definitions may be found by clicking on the "OMB Race Category" link.

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VIP Variant in P2RY1

The platelet responses to antithrombotic drugs like aspirin or clopidogrel are considerably variable among individuals. To identify patients who do not derive protection from aspirin therapy, the association between SNP in four candidate genes (ITGB3, PTGS1, PTGS2, P2RY1) implicated in the platelet aggregation pathway and aspirin resistance was investigated. A group of 332 white men with a history of myocardial infarction who underwent percutaneous coronary intervention were genotyped for seven SNPs (two in the P2RY1 gene: 893C>T and 1622A>G). All patients were on an aspirin regimen with a dosage of 81 mg/day [Article:15757620]. The study found only one polymorphism in the P2RY1 gene that was significantly associated with aspirin resistance. The C to T base substitution at position 893 (rs1065776) of the P2RY1 gene was associated with a >3-fold increase in aspirin resistance, whereas the 1622A>G polymorphism (rs701265) showed no association [Article:15757620].
Another study aimed to evaluate the association of SNPs in PTGS1, P2RY1, and ITGB3 genes with response to aspirin in healthy Chinese volunteers. A total of 24 subjects participated in the prospective aspirin trial including seven subjects with 893CC-1622GG genotype, five subjects with 893CC-1622AG genotype, six subjects with 893CC-1622AA genotype, and six subjects with 893CT-1622AG genotype. The results showed a significantly larger reduction in mean platelet aggregation after aspirin treatment in the P2RY1 893CT-1622AG genotype versus the other three genotypic groups with an 893CC genotype background [Article:17559347]. These finding are at odds with the study described above, which observed an increased frequency of the 893T allele in the aspirin-resistant individuals. The researchers argue that the difference in their subjects demographics and health status might contribute to this discrepancy [Article:17559347].
Li et al. summarized the genotype frequencies of both P2RY1 polymorphisms found in the coding region of the gene [Article:17559347]. For the 893C>T SNP, they compared their results obtained in healthy Chinese volunteers with a study on Caucasians with a history of myocardial infarction who underwent percutaneous coronary intervention [Article:15757620]. For the 1622A>G variant, the comparative study had Caucasians with no history of coronary heart disease enrolled [Article:15514209].

Publications related to rs1065776 at chr3:152553628: 2

VIP	Frequency of genetic polymorphisms of COX1, GPIIIa and P2Y1 in a Chinese population and association with attenuated response to aspirin. Pharmacogenomics. 2007. Li Qing, et al. [Article:17559347@PubMed]
VA VIP	Aspirin resistance and a single gene. The American journal of cardiology. 2005. Jefferson Brian K, et al. [Article:15757620@PubMed]

Cross-References

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